Articles

THERAPY WITH CHIMERIC ANTIGEN RECEPTOR T-CELLS. OVERVIEW OF CLINICAL EFFICACY AND PROSPECTS FOR IMPLEMENTATION IN KAZAKHSTAN

G. Zauatbayeva M. Zhumabekova A. Shustov
https://doi.org/10.11134/btp.3.2026.1
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DISTRIBUTION OF KRAS/BRAF GENE MUTATIONS IN METASTATIC COLORECTAL CANCER IN KAZAKHSTAN PATIENTS

G.N. Kulmambetova A.D. Gusmaulemova B.A. Kurentay D.S. Bayanbek D.N. Auganova P.V. Tarlykov M.A. Mamlin
https://doi.org/10.11134/btp.3.2026.2
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PREVALENCE, INFECTION INTENSITY, AND ALLERGENIC RISK OF ANISAKIS SPP. IN READY-TO-EAT FISH PRODUCTS

K. Jazina A. Bulashev A. Smagulova A. Izbasarova M. Kirjušina L. Lider V. Kiyan R. Uakhit
https://doi.org/10.11134/btp.3.2026.3
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DEVELOPMENT AND OPTIMIZATION OF AN ELISA TEST SYSTEM FOR THE QUANTITATIVE DETERMINATION OF ALPHA-FETOPROTEIN

S. Kan R. Tleulieva N. Abdolla N. Nurgalieva Yu. Perfilyeva Ye. Ostapchuk
https://doi.org/10.11134/btp.3.2026.4
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ADDRESSING A MANUFACTURING BOTTLENECK IN CAR-T THERAPY: SCALABLE PRODUCTION OF TRANSFECTION-GRADE PLASMID DNA FOR CAR-T VECTOR MANUFACTURING

E. Bulatov G. Nigmatulla V. Keyer T. Kulatay B. Ingirbay A. Kydyrbayeva M. Zhumabekova D. Zharlyganova A. Shustov
https://doi.org/10.11134/btp.3.2026.5
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PRODUCTION OF RACTOPAMINE-SPECIFIC ANTIBODIES FOR THE DETECTION OF GROWTH PROMOTER RESIDUES IN MEAT PRODUCTS

G.K. Kaukabayeva S.E. Mukhlis Z.S. Akhmetkarimova S.Z. Yeskendirova
https://doi.org/10.11134/btp.3.2026.6
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DEVELOPMENT AND OPTIMIZATION OF A TARGETED NGS PANEL FOR MODY DIAGNOSIS

A. Toleuzhanova A. Romanova E. Zholdybayeva R. Kalendar
https://doi.org/10.11134/btp.3.2026.7
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CHARACTERIZATION OF THE YELLOW FEVER VIRUS REPLICATION COMPLEX USING AN NS1–GFP REPLICON

D. Auganova S. Atavliyeva B. Ingirbay S. Baduanova A. Shustov P. Tarlykov
https://doi.org/10.11134/btp.3.2026.8
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INVESTIGATION OF SUBSTRATE SPECIFICITY AND KINETIC PARAMETERS OF ESTERASE FROM THE SPOROGENIC STRAIN BACILLUS PARALICHENIFORMIS T7

A. Mussakhmetov M. Astrakhanov Z. Akishev B. Khassenov
https://doi.org/10.11134/btp.3.2026.9
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MOLECULAR GENETIC CHARACTERIZATION AND OPTIMIZATION OF EX VITRO ADAPTATION AND ACCLIMATIZATION OF ENDANGERED BERBERIS ILIENSIS M. POP. MICROSHOOTS

A. Nurtaza A. Yessimseitova D. Dyussembekova G. Abileva S. Bayanbay K. Narmakhan D. Nurumov A. Kakimzhanova
https://doi.org/10.11134/btp.3.2026.10
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STATISTICAL, MOLECULAR, AND ULTRASTRUCTURAL INSIGHTS INTO THE STRESS-ALLEVIATING POTENTIAL OF AUTOCHTHONOUS STEPPE BACTERIAL LINEAGES

Zh.Zh. Zhaksybek A.K. Sattarova S.K. Abeldenov A.R. Zhumakayev
https://doi.org/10.11134/btp.3.2026.11
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RAPID DETECTION OF THE BLATEM GENE IN ACINETOBACTER BAUMANNII USING RPA ISOTHERMAL AMPLIFICATION AND THE CRISPR/CAS12A SYSTEM

M. Amanzholova A. Akimbekova A. Shaizadinova N. Sutimbekova N. Bissenova P. Tarlykov S. Abeldenov
https://doi.org/10.11134/btp.3.2026.12
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PRODUCTION OF RECOMBINANT LACTASE FROM Lactobacillus helveticus VA FOR APPLICATION IN ADVANCED MILK PROCESSING TECHNOLOGIES

Y.A. Shamsiyeva A.T. Kostanova A.E. Tursunbekova B.B. Khassenov Zhiger Akishev
https://doi.org/10.11134/btp.3.2026.13
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CRYOPRESERVATION OF SAIGA (SAIGA TATARICA) SOMATIC CELLS: EFFECT OF NON-EQUILIBRIUM AND EQUILIBRIUM FREEZING ON FIBROBLAST VIABILITY

Ye. Toishibekov A. Grachev M. Salmenova T. Nurkenov B. Katubayeva D. Toishybek I. Kumayeva A. Khamchukova M. Bespalov S. Bespalov S. Saparbayev S. Kantarbayev A. Chimiruk
https://doi.org/10.11134/btp.3.2026.14
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VITRIFICATION OF SAIGA (SAIGA TATARICA) SKIN FIBROBLASTS: EFFECT OF CRYOPROTECTANT COMPOSITION AND ULTRA-RAPID COOLING AT −205 °C

Ye. Toishibekov A. Grachev M. Salmenova T. Nurkenov B. Katubayeva D. Toishybek I. Kumayeva A. Khamchukova M. Bespalov S. Bespalov S. Saparbayev S. Kantarbayev A. Chimiruk
https://doi.org/10.11134/btp.3.2026.15
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EFFECT OF CONDITIONED MEDIUM FROM 3D SPHEROIDS OF HUMAN UMBILICAL CORD MESENCHYMAL STEM CELLS ON ENDOTHELIAL CELL MIGRATION IN AN IN VITRO WOUND-HEALING MODEL

Sh. Mukhlis M. Imanbekova A. Nurgaliyeva N. Altaeva M. Ashikbayeva V. Ogay A. Ospanova3
https://doi.org/10.11134/btp.3.2026.16
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A PRACTICAL WORKFLOW FOR MASCOT-BASED PROTEIN IDENTIFICATION AND POST-TRANSLATIONAL MODIFICATION ANALYSIS

S. Makhsatova A. Kurmanbay A. Kulyyassov
https://doi.org/10.11134/btp.3.2026.17
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DEVELOPMENT OF A PCR TEST SYSTEM FOR THE GENETIC DIAGNOSIS OF HEMORRHAGIC FEVER WITH RENAL SYNDROME

A.K. Rysbekova Z.B. Zhumadilova D.T. Yessimseit D.B. Khaltayeva A.K. Salavatov B.Z. Abdeliyev A.A. Abdirassilova N.B. Tukhanova N.A. Turebekov S.K. Umarova G.Zh. Tokmurziyeva B.A. Iztleuov N.U. Khakimov
https://doi.org/10.11134/btp.3.2026.18
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IODINE COORDINATION COMPOUNDS OF ANTI-INFLAMMATORY DRUGS: NEW SYSTEMS OF INTEREST FOR ANTI-INFECTIVE RESEARCH

D.A. Shepilov S. Turganbay A.B. Jumagaziyeva Zh.A. Iskakbayeva S.M. Jumabayeva A.B. Seysembekova Jingcheng Hao D. Askarova A.A. Azembayev
https://doi.org/10.11134/btp.3.2026.19
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COMPARISON OF THE EFFECTIVENESS OF THE EXPERIMENTAL KIT DEVELOPED FOR EXOSOME ISOLATION COMPARED WITH A COMMERCIAL KIT IN RELEVANT MODELS

A.Ye. Sekenova Ye.A. Sharapatov M.Ye. Shakhatbayev V.B. Ogay N.M. Mussin
https://doi.org/10.11134/btp.3.2026.20
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OBTAINING OF AN EXPERIMENTAL RETINOPATHY MODEL IN RABBITS USING REPEATED INTRAVITREAL ADMINISTRATION OF VEGF AND BFGF

A. Issabekova M. Sarsenova A. Dairov M. Shakhatbayev Ch. Assylbayev M. Baidarbekov E. Kadralieva Zh. Urazayeva V. Ogay
https://doi.org/10.11134/btp.3.2026.21
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DEVELOPMENT AND PRELIMINARY ANALYTICAL EVALUATION OF REAL-TIME PCR ASSAYS FOR AFRICAN SWINE FEVER VIRUS DETECTION

R. Nissanova E. Bashenova S. Kaimoldina V. Strochkov A. Karabassova P. Akshalova Zh. Abay Zh. Makay Zh. Tlegenova A. Nurpeisova M. Kassenov
https://doi.org/10.11134/btp.3.2026.22
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EVALUATION OF THE BIOLOGICAL ACTIVITY OF ORTHOPOXVIRUS STRAINS IN PRIMARY CHICKEN EMBRYO FIBROBLASTS

B.S. Myrzakhmetova G.A. Zhapparova L.B. Kutumbetov T.M. Tlenchieva A.B. Zhumabek A.M. Tuyakov A.V. Azanbekova K.D. Zhugunissov
https://doi.org/10.11134/btp.3.2026.23
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COMPARATIVE STUDY OF ELISA STOP SOLUTIONS BASED ON MINERAL ACIDS

B.M. Ismagambetov S.E. Shomanova I.A. Akhazhanova N.B. Esimbekova Z.D. Ershebulov
https://doi.org/10.11134/btp.3.2026.24
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PRODUCTION OF HYPERIMMUNE SERUM AGAINST RECOMBINANT PROTEINS SODC AND OMP16 OF BRUCELLA SPP. FOR THE DEVELOPMENT OF AN ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA) TEST SYSTEM

N.K. Orazymbetova Zh.K. Koshemetov O.V. Chervyakova B.K. Umuraliev O.N. Serikbaiov V.Zh. Kaukarbaeva A.A. Issakhan A.K. Adalbekova A.U. Issabek A.K. Bopi
https://doi.org/10.11134/btp.3.2026.25
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LABORATORY-SCALE CULTIVATION OF THE OSPA-VAKTSINA VACCINIA VIRUS STRAIN IN VERO CELLS ON BIONOC II® MACROCARRIERS USING THE BELLOSTAGE™-3000 SYSTEM

Zh.T. Amanova Zh.Zh. Sametova Ye.A. Bulatov
https://doi.org/10.11134/btp.3.2026.26
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OPTIMIZATION OF SERUM-FREE CULTIVATION OF RECOMBINANT SHEEPPOX VIRUS SSPV (TK) OMP16 IN VERO CELLS

Ye.B. Burashev R.A. Rystaeva Z.D. Omarova T.U. Argimbaeva N.A. Aubakir A.B. Tulendibayev T.T. Yermekbai S.O. Sadikaliyeva K.D. Zhugunissov O.V. Chervyakova
https://doi.org/10.11134/btp.3.2026.27
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VALIDATION OF KASP MARKERS FOR ADAPTATION AND YIELD-RELATED TRAITS IN SPRING BREAD WHEAT BREEDING LINES OF KAZAKHSTAN

A.Y. Amalova T.V. Savin S.I. Abugalieva Y.K. Turuspekov
https://doi.org/10.11134/btp.3.2026.28
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A DETECTION OF FIELD NEWCASTLE DISEASE VIRUS GENOTYPE VII AND INFECTIOUS BURSAL DISEASE VIRUS IN A COMMERCIAL LAYING FLOCK IN THE AKMOLA REGION

K.R. Ivanova M.A. Kopochenya D.A. Naizabayeva A.V. Zhigailov
https://doi.org/10.11134/btp.3.2026.29
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DEVELOPMENT AND STANDARDIZATION STRATEGY FOR QUALITY CONTROL OF A RECOMBINANT CAPRIPOXVIRUS-VECTORED VACCINE AGAINST BRUCELLOSIS

K.K. Jekebekov S.U. Moldagulova A.S. Zhakypbek Ye.A. Shayakhmetov A. Ulankyzy Zh.S. Absatova G.D. Nakhanova E.Zh. Kalimolda E.P. Voronina T.I. Baiseit A.D. Omurtay S.O. Sadikaliyeva E.A. Bulatov Zh.T. Amanova K.A. Shorayeva S.Sh. Nurabayev O.V. Chervyakova
https://doi.org/10.11134/btp.3.2026.30
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OPTIMIZATION OF GENOME-WIDE SNP MICROARRAY DATA PROCESSING FOR GENERATION OF AN ATHLETE GENETIC PROFILE

T.N. Kereyev A.V. Mustafayeva Zh.A. Zhaniyazov N.K. Altynova G.S. Zhunussova L.B. Djansugurova N.M. Kassymbek S.T. Mukhambetzhanov
https://doi.org/10.11134/btp.3.2026.31
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PREPARATION OF EFFECTIVE DIAGNOSTIC REAGENTS SUITABLE FOR ELISA IN THE DIAGNOSIS OF BACILLUS ANTHRACIS

B.K. Umuraliyev O.N. Serikbayov N.K. Orazymbetova A.A. Issakhan M.Zh. Kaukarbayeva A.K. Adalbekova R.Z. Nurgaziev M.S. Seisenbayeva Zh.K. Khoshemetov
https://doi.org/10.11134/btp.3.2026.32
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A REVIEW OF THE CLINICAL TRANSLATION OF NANOEMULSIONS, DOXIL AND LIPID NANOPARTICLES

Xianghua Yang Shiqi Liu Yixiang Su Haoxiang Yang Didar Baimanov1
https://doi.org/10.11134/btp.3.2026.33
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STABILITY OF AN ELISA TEST SYSTEM BASED ON A RECOMBINANT CHIMERIC SM PROTEIN FOR THE DETECTION OF ANTIBODIES TO SARS-COV-2 UNDER DIFFERENT TEMPERATURE CONDITIONS

G.D. Nakhanova O.V. Chervyakova A.T. Zhunushov A.K. Nakhanov A. Ulankyzy A.S. Zhakypbek A. Tileukhanova K.A. Shorayeva
https://doi.org/10.11134/btp.3.2026.34
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BIOTECHNOLOGICAL ACTIVATION OF GREEN LENTILS BY GERMINATION AND EVALUATION OF THEIR ANTIOXIDANT POTENTIAL FOR APPLICATION IN MEAT PRODUCT TECHNOLOGY

M. Iliyaskyzy A. Kaliyeva A. Sartayeva R. Ukibayev B. Temirkhan
https://doi.org/10.11134/btp.3.2026.35
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PHYSIOLOGICAL, BIOCHEMICAL, AND MOLECULAR CHARACTERIZATION OF THE RESPONSE OF POTATO CULTIVAR ASTANALYK TO OSMOTIC STRESS

A.K. Argumbayeva B.R. Kali L.S. Abeuova B.N. Nasiev Sh.A. Manabayeva
https://doi.org/10.11134/btp.3.2026.36
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CRYOPRESERVATION OF SKIN FIBROBLASTS OF THE SNOW LEOPARD (PANTHERA UNCIA) FROM KAZAKHSTAN: PASSIVE SLOW FREEZING VERSUS CONTROLLED-RATE FREEZING WITH DIMETHYL SULFOXIDE OR ETHYLENE GLYCOL

Ye. Toishibekov A. Grachev M. Salmenova T. Nurkenov B. Katubayeva D. Toishybek I. Kumayeva M. Bespalov S. Bespalov S. Saparbayev
https://doi.org/10.11134/btp.3.2026.37
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EFFECT OF THE CATALYTIC SYSTEM AND POLYMERIZATION TIME ON THE CHARACTERISTICS OF POLY(OEGMA) AND POLY(CBMA) SYNTHESIZED BY ATRP

B. Kaupbayeva A. Tsoy H. Murata A. Kassenova Sh. Askarova
https://doi.org/10.11134/btp.3.2026.38
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FLUORESCENCE IMAGING CAPABILITIES IN SECONDARY LYMPHEDEMA FOLLOWING COMPREHENSIVE TREATMENT OF MALIGNANT NEOPLASMS: A CASE SERIES

Y.B. Gazizova U.Y. Kairov D.A. Begimbetova A.K. Makishev A.M. Kukanova
https://doi.org/10.11134/btp.3.2026.39
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CLINICAL EFFICACY AND SAFETY OF VANDETANIB IN METASTATIC MEDULLARY THYROID CARCINOMA: A CASE REPORT

A.R. Zhanymbetova D.A. Begimbetova A.K. Kukanova U.Y. Kairov A.T. Bakisheva A.K. Makishev
https://doi.org/10.11134/btp.3.2026.40
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EXPLORING THE INTRAVENOUS COMBINATION OF D-ISOASCORBIC ACID (D-VC) AND ARSENIC TRIOXIDE IN ADVANCED/METASTATIC MALIGNANCIES

B.A. Yermekbayeva U.Y. Kairov D.A. Begimbetova A.M. Kukanova A.K. Makishev
https://doi.org/10.11134/btp.3.2026.41
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WHOLE-EXOME SEQUENCING OF MONOZYGOTIC TWINS WITH EPILEPSY AND AUTISM SPECTRUM DISORDER IN A KAZAKHSTANI FAMILY: A CASE REPORT

A.K. Gabdulkayum Zh.Zh. Mirmanova A.Zh. Daniyarov N.N. Satvaldina A.S. Kudaibergenov Zh.A. Medetbekova S. Amangeldikyzy A. Giniyat A.R. Akilzhanova D.A. Yerezhepov
https://doi.org/10.11134/btp.3.2026.42
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GENETIC INSIGHTS INTO А KAZAKHSTANI FAMILY WITH MULTIPLE NEUROLOGICAL CONDITIONS: A CASE REPORT

A. Gabdulkayum Zh. Mirmanova A. Daniyarov Zh. Medetbekova A. Kudaibergenov S. Amangeldikyzy A. Giniyat A. Yerezhepov A. Aitkulova A. Akilzhanova D. Yerezhepov
https://doi.org/10.11134/btp.3.2026.43
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PREDICTIVE MODELING OF RICE GERMINATION SENSITIVITY TO SALINITY USING LITERATURE-DERIVED DATA

A. Samat A. Yesseneyev M. Bralina D. Talgatbekova A. Kurmanbayeva Zh. Bekshin Zh. Tekebayeva A. Tuyakbayeva A. Bekturova A. Temirkhanov Zh. Nurbekova
https://doi.org/10.11134/btp.3.2026.44
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A SYSTEMATIC REVIEW AND META-ANALYSIS OF THE CLINICAL EFFICACY AND SAFETY OF BACTERIOPHAGES IN BACTERIAL INFECTIONS

N.S. Sikhayeva A.S. Dyussenbekova K.B. Bekeshova N.A. Esenbekova Zh.D. Kanalyn A.S. Rsaliyev Y.O. Abduraimov
https://doi.org/10.11134/btp.3.2026.45
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