No. 3s (2025) | Eurasian Journal of Applied Biotechnology

Genomic studies at Center for Life Sciences- paving the way for personalized medicine in Kazakhstan

Ainur R. Akilzhanova

https://doi.org/10.11134/btp.3s.2025.1

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Genetic spectrum of channelopathies in Kazakhstani patients revealed by targeted NGS panel

Ayaulym Chamoieva Zhanel Mirmanova Madina Zhalbinova Saule Rakhimova Ulykbek Kairov Ainur Akilzhanova

https://doi.org/10.11134/btp.3s.2025.2

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Association of multi drug resistant tuberculosis with the beijing family of m.tuberculosis in Kazakhstan

Zh. Abilova A. Akhmetova T. Kadenova N. Satvaldina A. Daniyarov U. Kairov A. Akilzhanova J. Almazan U. Kozhamkulov

https://doi.org/10.11134/btp.3s.2025.3

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VDR Gene Polymorphisms are Associated with Vitamin D Insufficiency in Elite Male Power Athletes of Kazakhstan

Aidana Gabdulkayum Saya Amangeldikyzy Adil Yerezhepov Sayipzhamal Khassanova Kenes R. Akilzhanov Ulan Kozhamkulov Saule Rakhimova Ulykbek Kairov Ainur Akilzhanova Dauren Yerezhepov

https://doi.org/10.11134/btp.3s.2025.4

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The biodiversity of lichens and their biomedical potential

A.Zh. Zhumaniyazova Zh.T. Bukabayeva B.M. Silybayeva

https://doi.org/10.11134/btp.3s.2025.5

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Immunological and Genetic Features of Thyroid-Associated Ophthalmopathy

Ainura Mussakulova Gulnur Zhunussova Altynay Balmukhanova Aigul Balmukhanova

https://doi.org/10.11134/btp.3s.2025.6

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miR-423-3p as a Biomarker of Diabetic Retinopathy in Patients with Type 2 Diabetes in the Kazakh Population

Aizhan Magazova Aigul Balmukhanova Kamalidin Sharipov Yeldar Ashirbekov

https://doi.org/10.11134/btp.3s.2025.7

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Chromosome-scale assembly of Kazakh individuals using modern genomics approaches

Aiziya Paizulla Kuanysh Sarkytbayev Anel Ordabayeva Asset Daniyarov Askhat Molkenov Diana Samatkyzy Saule Rakhimova Ainur Akilzhanova Ulykbek Kairov

https://doi.org/10.11134/btp.3s.2025.8

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Immunohistochemical markers in colorectal adenocarcinoma

Akbota Aitkulova Tomiris Kadenova Tatiana Rogounovitch Saule Rakhimova Ainur Akilzhanova Dos Sarbassov

https://doi.org/10.11134/btp.3s.2025.9

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Cytomegalovirus infection in young children

Alyona Altynbekova Turdalina Bayan Mussina Albina Aliya Seidullayeva

https://doi.org/10.11134/btp.3s.2025.10

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Comparative evaluation of ANNOVAR, OpenCRAVAT, and Nirvana workflows for variant annotation in large-scale WGS studies

Asset Daniyarov Rakhmetkazhi Bersimbaev Ulykbek Kairov

https://doi.org/10.11134/btp.3s.2025.11

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Whole-Genome Sequencing Reveals Genetic Variants in Pediatric Epilepsy Patients of Kazakhstan

Dauren Yerezhepov Aidana Gabdulkayum Nazerke Satvaldina Saule Rakhimova Mirgul Bayanova Ulykbek Kairov Ainur Akilzhanova

https://doi.org/10.11134/btp.3s.2025.12

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Development of a Clinical Trial Protocol for the Use of a Dual GIP/GLP-1 Receptor Agonist in Patients with Heart Failure with Preserved Ejection Fraction

Diana Samatkyzy Bakytgul Yermekbayeva Saule Rakhimova Ayaulym Chamoieva Ainur Tauekelova Laura Danyarova Dos Sarbassov Ainur Akilzhanova

https://doi.org/10.11134/btp.3s.2025.13

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Metabolomics-based prediction model for diabetes: A comprehensive analysis of biomarkers and machine learning approaches

Doaa Farid Farhana Saleh Tareq Mohammed Atika Nigar Abderrahmane Maaradji

https://doi.org/10.11134/btp.3s.2025.14

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Rare Mutations in Patients with Brain Arteriovenous Malformations

Elena Zholdybayeva Ayazhan Bekbayeva Alua Gusmaulemova Botakoz Kurentay

https://doi.org/10.11134/btp.3s.2025.15

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Pathogenic Germline Variants in Very Early Onset Colorectal Cancer Patients in Kazakhstan

Nurlan Baltayev Saltanat Abdikerim Georgiy Afonin Dilyara Kaidarova Gulnur Zhunussova

https://doi.org/10.11134/btp.3s.2025.16

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Genetic Mapping and Meta-QTL Analysis of Traits Associated with Drought Tolerance in Wheat

Kuanysh Zhapar Ainur Akilzhanova Sarbassov Dos

https://doi.org/10.11134/btp.3s.2025.17

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Pathogen Analysis in Ancient Individuals from the Central Eurasian Region

Lyazzat Musralina Aigerim Kasymbekova Saida Tokmurzina Aikorkem Mustafayeva Zhantuar Kumarbekov Zhasulan Zhaniyazov Nazym Altynova Leyla Jansugurova

https://doi.org/10.11134/btp.3s.2025.18

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Integrating Genetic Susceptibility and Air Pollution Exposure to Predict Asthma Risk in an Urban Kazakh Population

Madina Abdullayeva Aigerim Kassymbekova Kanagat Yergali Alexander Garshin Danara Artygaliyeva Lina Lebedeva Lyazzat Musralina Leyla Djansugurova Nazym Altynova

https://doi.org/10.11134/btp.3s.2025.19

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Role of genetic polymorphisms in preventing complications development in heart failure patients

Madina Zhalbinova Saule Rakhimova Ulan Kozhamkulov Ayalum Chamoieva Zhanel Mirmanova Makhabbat Bekbosynova Ainur Akilzhanova

https://doi.org/10.11134/btp.3s.2025.20

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Generation of induced pluripotent stem cells (iPSCs) for modeling catecholaminergic polymorphic ventricular tachycardia (CPVT)

Nazerke Satvaldina Ainur Tolymbekova Saule Rakhimova Zhannur Abilova Ainur Akilzhanova

https://doi.org/10.11134/btp.3s.2025.21

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Embryonic Organogenesis under the Effect of Dual GLP-1/GIP Receptor Agonist

Omirgul Bakenova Galiya Akylzhanova Arslan Umarov Danysh Abetov Zhanna Mussaeva Ainur Akilzhanova Dos Sarbassov

https://doi.org/10.11134/btp.3s.2025.22

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Whole Exome Sequencing Identifies Rare NR1H3 Variants Linked to Fatty Liver and Atherosclerosis

Rassul Shokenov Zhanel Mirmanova Madina Zhalbinova Ayaulym Chamoieva Tomiris Shakhmarova Nazerke Satvaldina Saule Rakhimova Ulykbek Kairov Asset Daniyarov Makhabbat Bekbossynova Ainur Akilzhanova

https://doi.org/10.11134/btp.3s.2025.23

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A nucleic acid universal purification, isolation method and device

Ruslan Kalendar

https://doi.org/10.11134/btp.3s.2025.24

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Systems-level analysis of androgen in aging and age-related diseases: a network pharmacology, molecular docking and microbiota-integrated approach

Kassym Imankulov Inzhu Sariyeva Safura Kudiyar Leila Bolat Mirat Nurtileu

https://doi.org/10.11134/btp.3s.2025.25

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Comparative genomic profiling of primary tumor tissue and circulating tumor DNA in Colorectal Cancer

Tomiris Kadenova Nuray Tynyshtykbayeva Asset Z. Daniyarov Saule Rakhimova Akbota Aitkulova Ainur Akilzhanova Dos Sarbassov

https://doi.org/10.11134/btp.3s.2025.26

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Towards a quantitative assessment of the mitochondrial component of aging: the fragility score as an indicator of the risk of mtDNA deletion formation

Victor Shamanskiy Evgenii O. Tretiakov Konstantin Gunbin Konstantin Popadin

https://doi.org/10.11134/btp.3s.2025.27

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Prevalence of damaging genetic variants in genes of lipid metabolism pathway in Kazakhstani atherosclerosis cohort

Zhanel Mirmanova Madina Zhalbinova Ayaulym Chamoieva Tomiris Shakhmarova Nazerke Satvaldina Saule Rakhimova Ulykbek Kairov Asset Daniyarov Makhabbat Bekbossynova Ainur Akilzhanova

https://doi.org/10.11134/btp.3s.2025.28

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Clonal Hematopoiesis of Indeterminate Potential Mutations and Cardiovascular Risk in Kazakhstani Cohort

Tomiris Shakhmarova Zhanel Mirmanova Madina Zhalbinova Ayaulym Chamoieva Nazerke Satvaldina Saule Rakhimova Ulykbek Kairov Asset Daniyarov Makhabbat Bekbossynova Ainur Akilzhanova

https://doi.org/10.11134/btp.3s.2025.29

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Genomic landscape of the Great Steppe: Genetic variants in healthy Kazakh individuals

Aygerim Serikzhan Asset Daniyarov Ainur Akhmetova Zhannur Abilova Askhat Molkenov Dauren Yerezhepov Saule Rakhimova Ulan Kozhamkulov Almagul Kushugulova Sholpan Askarova Dos Sarbassov Ainur Akilzhanova Ulykbek Kairov

https://doi.org/10.11134/btp.3s.2025.30

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Distinct regional focal adhesion dynamics explored by automated quantitative analysis

Vadim Mustyatsa Arina Zhuravel Nurdaulet Kulsharip Iliyas Marat Madina Tlegenova Aisulu Anapina Aleena Saidova Ivan Vorobjev

https://doi.org/10.11134/btp.3s.2025.31

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Evaluation of CCR5 inhibition in breast cancer using novel, potent inhibitors

Laura Bakyt Denis Bulanin

https://doi.org/10.11134/btp.3s.2025.32

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Restoring drug sensitivity in colorectal cancer through Cdc42 inhibition

Aislu Yermekova Aibanu Sailauova Bauyrzhan Umbayev Altyn Zhuraliyeva

https://doi.org/10.11134/btp.3s.2025.33

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Molecular and cellular effects of low-dose Chrysotile Asbestos exposure in human lung fibroblasts

Assiya Kussainova Olga Bulgakova Akmaral Aripova Rakhmetkazhi Bersimbaev

https://doi.org/10.11134/btp.3s.2025.34

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NKG2DL as a promising targets for colorectal cancer immunotherapy

Alexey Petukhov Shynggys Tursymbek Nikolai Barlev

https://doi.org/10.11134/btp.3s.2025.35

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Identification of Recurrent Fusion Genes in Esophageal Squamous Cell Carcinoma Patients from Kazakhstan

Aibek Karimov Rakhimbek Bektayev Ruslan Kalendar Aigul Sharip Saule Rakhimova Nazerke Satvaldina Ainur Seisenova Ainur Akilzhanova Ulykbek Kairov

https://doi.org/10.11134/btp.3s.2025.36

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Development of CASIN-Encapsulated PLGA-PEG Nanoparticles for Colorectal Cancer Treatment

Altyn Zhuraliyeva Bauyrzhan Umbayev Sanazar Kadyr Aislu Yermekova Aigerim Makhambetova Daulet Kaldybekov Ellina Mun Denis Bulanin Sholpan Askarova

https://doi.org/10.11134/btp.3s.2025.37

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Carbon dots derived from Aicao (Artemisia argyi) and Honey induce cancer cell death by targeting MET kinase

Aigerim Tassanbiyeva Gulziya Toktau Hujie Song Yingqiu Xie

https://doi.org/10.11134/btp.3s.2025.38

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CD3+CD4-CD8- T cells in pediatric leukemia

Kuanysh Dossybayeva Dana Tleugozhina Gulsamal Zhubanova Assel Mussayeva Assem Kurmangali Ayana Ablayeva Dair Nurgaliyev Zabira Kyzdarbekova Kundyz Shaykhyzada Galiya Nauryzbayeva Ulbolsyn Orumbayeva Kadisha Nurgaliyeva Matthew Tanko Dimitri Poddighe Lyudmila Akhmaltdinova

https://doi.org/10.11134/btp.3s.2025.39

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Integrative analysis of lncRNA-miRNA-mRNA expression profiles in esophageal squamous cell carcinoma tissues

Kuanysh Sarkytbayev Anel Ordabayeva Asset Daniyarov Askhat Molkenov Aigul Sharip Saule Rakhimova Nazerke Satvaldina Ainur Seisenova Ulan Kozhamkulov Ainur Akilzhanova Ulykbek Kairov

https://doi.org/10.11134/btp.3s.2025.40

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Redox-Modulatory and MET-Inhibitory Triad: Synergistic Cytotoxicity of L-cysteine, NAC, and MET Inhibition in Cervical Cancer Cells

Aigerim Tassanbiyeva Aruzhan Onggarbek Yingqiu Xie

https://doi.org/10.11134/btp.3s.2025.41

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Oncogene-dependent mitochondrial dynamics and its therapeutic modulation in colorectal cancer cell lines

Darina Mukhamejanova Ainur Sibagatova Alexey Petukhov Marina Yelsyukova Bayansulu Ilyassova Kristina Raish Dos Sarbassov Agata Burska

https://doi.org/10.11134/btp.3s.2025.42

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Fusobacterium nucleatum in colorectal cancer

Gulmira Kulmambetova Botakoz Kurentay Dina Bayanbek Alua Gusmaulemova

https://doi.org/10.11134/btp.3s.2025.43

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Prolonged Inhibition of Cell Proliferation by Short-Term Exposure to Certain Anti-Mitotic Drugs

Arsen Orazbek Ivan Vorobyev

https://doi.org/10.11134/btp.3s.2025.44

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Semi-distributed interferometers for early detection of lung cancer biomarkers

Adina Almakhambetova Aisha Dauletkyzy Bauyrzhan Kizatov Azhar Mukash Madina Pirman Aruzhan Turlybek Anastassiya Tyazhelova Daniele Tosi

https://doi.org/10.11134/btp.3s.2025.45

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Сharacterization of the probiotic potential of Lacticaseibacillus paracasei 2 LB strain

Gulayim Abitayeva Diana Kurmangali Temirlan Baikonys Zhandarbek Bekshin

https://doi.org/10.11134/btp.3s.2025.46

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Antibiotic Pressure at Sub-MIC Levels Shapes Bacteroides fragilis–Host Interactions Through Vesicle-Mediated Immunomodulation

Ayazhan Bekbayeva Elena Zholdybayeva Saniya Kozhakhmetova

https://doi.org/10.11134/btp.3s.2025.47

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Antimicrobial Activity of Cervical Lactobacillus Isolates

Viktoriya Nazarova Almagul Kushugulova

https://doi.org/10.11134/btp.3s.2025.48

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Effect of probiotics on the microbiome in drug-induced hepatitis

Zhanagul Khassenbekova Samat Kozhakhmetov Indira Uyzbayeva Akmaral Zhantureyeva Dinar Tarzhanova Almagul Kushugulova

https://doi.org/10.11134/btp.3s.2025.49

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Characterization of proteomic profile of the replication complex associated with the yellow fever virus

D. Auganova B. Ingirbay A. Shustov P. Tarlykov

https://doi.org/10.11134/btp.3s.2025.50

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Сhanges in infant gut microbiota associated with maternal obesity

Nurislam Mukhanbetzhanov Zharkyn Jarmukhanov Elizaveta Vinogradova Almagul Kushugulova Samat Kozhakhmetov

https://doi.org/10.11134/btp.3s.2025.51

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Genetically Engineered Microbiome as a New Treatment Option for Inflammatory Bowel Disease

Aizat Abdirassil Sanzhar Zhetkenev Ayidana Aidarkyzy Eva Riethmacher

https://doi.org/10.11134/btp.3s.2025.52

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Molecular genetic detection of bacterial vaginosis at kazakh women

A.Sh. Oradova

https://doi.org/10.11134/btp.3s.2025.53

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The role of premorbid background in the clinical picture of acute respiratory viral infections in children

A. Toleukhankyzy M.M. Muti D.A. Baesheva B.R. Turdalina

https://doi.org/10.11134/btp.3s.2025.54

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Antimicrobial Activity of Cervical Lactobacillus Isolates Against Candida glabrata (C. glabrata)

Tarazy Kadirgalikyzy Viktoriya Nazarova Almagul Kushugulova

https://doi.org/10.11134/btp.3s.2025.55

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Antagonistic activity of some bacterial and fungal isolates against wheat root pathogens

Nurlan Kuldybayev Aigerim Qairatova Zhanar Suleimenova Gulnar Dzhakibayeva Akmeiir Yelubayeva Yerlan Dutbayev

https://doi.org/10.11134/btp.3s.2025.56

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Synbiotic dairy products: development and quality assessment using probiotic cultures and prebiotic ingredients

T.S. Тasmaganbetova U.Z. Sagyndykov

https://doi.org/10.11134/btp.3s.2025.57

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Grape polyphenol concentrate in reducing the risk of phosphorus intoxication

Z. Mukhanbetzhanova S. Sergazy A. Nurgaziyeva

https://doi.org/10.11134/btp.3s.2025.58

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Metabolic Reprogramming of Macrophages Towards Regenerative Phenotype

Eugene D. Ponomarev

https://doi.org/10.11134/btp.3s.2025.59

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Experimental models in vivo are the basis of translational medicine

Svetlana Mankovskaya

https://doi.org/10.11134/btp.3s.2025.60

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TMEM9 subunits as new molecular regulators of endosomal chloride/proton exchangers

Rosa Planells-Cases Viktoriia Vorobeva Sumanta Kar Franziska W. Schmitt Uwe Schulte Marina Schrecker Richard K. Hite Bernd Fakler Thomas J. Jentsch

https://doi.org/10.11134/btp.3s.2025.61

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Hydrogel-Based Delivery System for Regeneration of Articular Cartilage Defects

Vyacheslav Ogay Assel Issabekova Tusipkhan Toktarov Yerik Raimagambetov

https://doi.org/10.11134/btp.3s.2025.62

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A new mouse model of amyotrophic lateral sclerosis with fus gene mutation: mechaniams of neuropathology and effects of standard and new treatments

Tatyana Strekalova

https://doi.org/10.11134/btp.3s.2025.63

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The challenges of performing a phase I and Phase II study with an autologous stem cell product Neuro-Cells® to combat neurodegeneration

Johannes P.J.M. de Munter

https://doi.org/10.11134/btp.3s.2025.64

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Study of the Therapeutic Effect of Cytokine-Preconditioned Mesenchymal Stem Cells and Their Exosomes in a Mouse Model of Psoriasis

Aidar Dairov Assel Issabekova Madina Sarsenova Aliya Sekenova Miras Shakhatbayev Symbat Alimbek Gulshakhar Kudaibergen Assiya Nurkina Ilyas Akhmetollayev Kyung-Sun Kang Vyacheslav Ogay

https://doi.org/10.11134/btp.3s.2025.65

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Sensitive detection of kidney injury biomarker (KIM1) in urine samples using an optical fiber semi-distributed interferometer biosensor

Kuanysh Seitkamal Anum Afroz Aigerim Tleuzhanova Zhalaliddin Makhammajanov Abduzhappar Gaipov Wilfried Blan Daniele Tosi Aliya Bekmurzayeva

https://doi.org/10.11134/btp.3s.2025.66

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Targeted Delivery of Cdc42 Inhibitor CASIN to Colorectal Cancer Cells via Nucleolin- Binding Aptamer-Functionalized PLGA-PEG Nanoparticles

Altyn Zhuraliyeva Sanazar Kadyr Bauyrzhan Umbayev Aislu Yermekova Aigerim Makhambetova Daulet Kaldybekov Ellina Mun Denis Bulanin

https://doi.org/10.11134/btp.3s.2025.67

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Characterization of human umbilical cord blood mesenchymal stem cell-derived exosomes by size and zeta potential analysis

Aidar Dairov Assel Issabekova Gulshakhar Kudaibergen Vyacheslav Ogay

https://doi.org/10.11134/btp.3s.2025.68

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Mesenchymal stem cell-derived exosomes for the treatment of skin and subcutaneous tissue diseases: current evidence from clinical trials

Aidar Dairov

https://doi.org/10.11134/btp.3s.2025.69

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COMPARISON OF THE TWO METHODS FOR ISOLATION OF EXOSOMES FROM hUC-MSCs

Aliya Sekenova Vyacheslav Ogay

https://doi.org/10.11134/btp.3s.2025.70

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Quantitative Detection of CD44-Expressing Cancer Cells Using Label-Free Optical Fiber Biosensors with Quasi-Random Interferometry

Marzhan Nurlankyzy Kanagat Kantoreyeva Aida Zhakypbekova Zhannat Ashikbayeva Damira Kanayeva Carlos Marques Santosh Kumar Milan Kovacevic Wilfried Blanc Constantinos Valagiannopoulos Aliya Bekmurzayeva Daniele Tosi

https://doi.org/10.11134/btp.3s.2025.71

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Development of a Pericyte-Based Therapy for Diabetic Retinopathy

Miras Shakhatbayev Symbat Alimbek Aidar Dairov Assel Issabekova Vyacheslav Ogay

https://doi.org/10.11134/btp.3s.2025.72

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Polymer-Engineered Aβ-Degrading Proteases via Photo-ATRP for Alzheimer's Disease Therapeutics

Andrey Tsoy Sholpan Askarova Bibifatima Kaupbayeva

https://doi.org/10.11134/btp.3s.2025.73

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Pharmacokinetics of Ceftriaxone Encapsulated in Autologous Erythrocytes

Kulzhan Berikkhanova Alexandr Gulyayev Yernur Zakirov Azhar Zhaisanova Nurgul Daniyeva Askhat Zhilkaidarov Nurzhan Bikhanov Erlan Taigulov Saken Kozhakhmetov Beybarys Amankeldin Yessenkhan Sultan Saniya Abdrakhmanova Zharas Bibekov Tatyana Kazakevich Zhaxybay Zhumadilov

https://doi.org/10.11134/btp.3s.2025.74

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