GENETIC VARIATIONS OF NUTRITION RELATED GENES AND FOOD PREFERENCES IN THE KAZAKHS OF KAZAKHSTAN
Main Article Content
Authors
N. Sikhayeva
National Center for Biotechnology, 13/5, Korgalzhyn road, Nur-Sultan, 010000, Kazakhstan
Y. Talzhanov
National Center for Biotechnology, 13/5, Korgalzhyn road, Nur-Sultan, 010000, Kazakhstan
Zh Dzharmukanov
National Center for Biotechnology, 13/5, Korgalzhyn road, Nur-Sultan, 010000, Kazakhstan
A. Shevtsov
National Center for Biotechnology, 13/5, Korgalzhyn road, Nur-Sultan, 010000, Kazakhstan
E. Zholdybayeva
National Center for Biotechnology, 13/5, Korgalzhyn road, Nur-Sultan, 010000, Kazakhstan
R. Karabayeva
Medical Center Hospital of President’s Affairs Administration of the Republic of Kazakhstan PI, E495 Mangilik el av, build 2, Nur-Sultan, 010000, Kazakhstan
V. Benberin
Medical Center Hospital of President’s Affairs Administration of the Republic of Kazakhstan PI, E495 Mangilik el av, build 2, Nur-Sultan, 010000, Kazakhstan
M. Filipenko
Institute of Chemical Biology and Fundamental Medicine Novosibirsk, Russia, 8 Lavrentiev Avenue, Novosibirsk, 630090, Russia
Y. Ramankulov
National Center for Biotechnology, 13/5, Korgalzhyn road, Nur-Sultan, 010000, Kazakhstan
Abstract
The density of taste buds, differences in genes encoding receptors, and other factors affect the on perception of taste and further food preferences. This study aimed to evaluate the association between 24 single nucleotide polymorphisms and food preferences in a Kazakh cohort. A total of 400 subjects were recruited from an outpatient clinic and genotyped for 24 polymorphisms previously described as associated with eating behaviour and food preferences in other ethnic groups. Regression analysis was conducted, adjusting for age and sex.
Associations were detected between rs2290550 polymorphism in phospholipase C-B2 (PLCB2), rs34160967 polymorphism in taste 1 receptor member 1 (TAS1R1) gene, and rs860170 polymorphism in TAS2R16 gene and preferences for beef steak, unleavened bread, and sweet tea or coffee, respectively. There was an association between AA haplotype (TAS2R38) and a preference for fried potato. The main results of this study are the detection of associations between nutrition-related genes (BCMO1, PLCB2, TRPV1, TAS1R1, and TAS2R) and food preferences in a Kazakh population.
Keywords
food preferences, genetic variants, Kazakh cohort, polymorphism
Article Details
References
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