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T.A. Sinyukova

Surgut State University, 1, Lenin St., Surgut, 628408, Khanty-Mansi Autonomous Okrug-Yugra, Russia

L.V. Kovalenko

Surgut State University, 1, Lenin St., Surgut, 628408, Khanty-Mansi Autonomous Okrug-Yugra, Russia

N.S. Kavushevskaya

Surgut State University, 1, Lenin St., Surgut, 628408, Khanty-Mansi Autonomous Okrug-Yugra, Russia

D.A. Lozhkin

Surgut State University, 1, Lenin St., Surgut, 628408, Khanty-Mansi Autonomous Okrug-Yugra, Russia

V.A. Shestakova

Surgut State University, 1, Lenin St., Surgut, 628408, Khanty-Mansi Autonomous Okrug-Yugra, Russia


In recent years, there has been a growing interest in elucidating the relationship between gut microbiota metabolism and cardiovascular disease. Certain metabolites of the gut microbiome: certain bile acids, short-chain fatty acids and trimethylamine N-oxide, may contribute to the development and progression of cardiovascular disease. It has been shown that trimethylamine N-oxide can exacerbate cardiovascular disease through the progression of atherosclerosis and thrombotic risks, and has been shown to be correlated with other cardiometabolic diseases such as non-alcoholic fatty liver disease and chronic kidney disease. One of the many factors affecting the level of formation of trimethylamine N-oxide in the human body is nutrition. This article examines the effect of food on the production of trimethylamine N-oxide. The analysis of the data showed that an increase in the synthesis of trimethylamine N-oxide can be influenced by products with an increased content of primary substrates, the composition of the human intestinal microbiome, and the method of cooking products. It should be noted that the concentration level of the oxidized form of trimethylamine can be reduced by some biologically active compounds containing polyphenols. Studies in this area are few and contradictory, which necessitates further research on the effect of food on the metabolism of trimethylamine and its oxidized form.


Trimethylamine, trimethylamine N-oxide, dietary effects on trimethylamine N-oxide, trimethylamine N-oxide metabolism, sources of trimethylamine

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