MAIN EPIDEMIOLOGICAL ASPECTS OF PANCREATIC CANCER IN KAZAKHSTAN
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Authors
F. Fazyl
PI "National Laboratory Astana", 53 Kabanbay batyr ave., Nur-Sultan, 010000, Republic of Kazakhstan
D Begimbetova
PI "National Laboratory Astana", 53 Kabanbay batyr ave., Nur-Sultan, 010000, Republic of Kazakhstan
K. Batyrbekov
National Research Oncology Center, Kerey, Zhanibek Khandar str., house 3, Nur-Sultan, 010000, Republic of Kazakhstan
Z. Spataev
National Research Oncology Center, Kerey, Zhanibek Khandar str., house 3, Nur-Sultan, 010000, Republic of Kazakhstan
Sh. Aitbaev
National Research Oncology Center, Kerey, Zhanibek Khandar str., house 3, Nur-Sultan, 010000, Republic of Kazakhstan
D. Sarbassov
PI "National Laboratory Astana", 53 Kabanbay batyr ave., Nur-Sultan, 010000, Republic of Kazakhstan
Abstract
According to GLOBOCAN (2020), pancreatic cancer (PC) is in 12th place among oncopathology in terms of incidence - 4.9 cases per 100,000 population. Most cases of pancreatic cancer are registered in China, the USA, Japan, and Germany. In the structure of mortality among oncological diseases, pancreatic cancer occupies 9th place - 4.5 cases per 100 thousand of the population. According to epidemiological studies, by 2040, a 79.9% increase in mortality from pancreatic cancer is predicted. According to statistics, in the United States, there is an increase in the incidence of cancer in the distal pancreas. In addition, early stages of pancreatic cancer were diagnosed more often and less often - the 4th. One of the trends in the epidemiology of pancreatic cancer is an increase in the incidence of this pathology among young people. Factors contributing to the development of pancreatic cancer in people under 50 years of age are genetic mutations, smoking, and obesity. A retrospective statistical analysis of the epidemiological state of pancreatic cancer in Kazakhstan over 3 years was carried out (standardized WHO World indicators per 100,000 population and intensive indicators of morbidity, mortality, distribution by stage, age, and sex), and regional features of pancreatic cancer were studied.
Keywords
pancreatic cancer, pancreas, epidemiology of pancreatic cancer, morbidity, mortality
Article Details
References
Ferlay, J., Soerjomataram, I., Ervik, M., Dikshit, R., Eser, S., Mathers, C., et al. GLOBOCAN 2020 Vol. 1.0, Cancer Incidence and Mortality Worldwide. IARC CancerBase N 11 [Electronic resource]. Lyon, France: International Agency for Research on Cancer. - 2020. Available from: URL
Indicators of the oncological service of the Republic of Kazakhstan for 2018: statistical and analytical materials edited by Kaidarova D.R., Dushimova Z.D., Shatkovskaya O.V., Ongarbaev B.T., Seisenbaeva G.T., Azhmagambetova A.E.,. Zhylkaidarova A.Zh, Lavrentiev I.K., Sagi M.S. - 2019. - Almaty. - JSC "KazNIIOiR". - P. 214.
Indicators of the oncological service of the Republic of Kazakhstan for 2019: statistical and analytical materials edited by Kaidarova D.R., Dushimova Z.D., Shatkovskaya O.V., Ongarbaev B.T., Seisenbaeva G.T., Azhmagambetova A.E.,. Zhylkaidarova A.Zh, Lavrentiev I.K., Sagi M.S. - 2020. - Almaty. - JSC "KazNIIOiR". - P. 230.
Indicators of the oncological service of the Republic of Kazakhstan for 2020: statistical and analytical materials edited by Kaidarova D.R., Dushimova Z.D., Shatkovskaya O.V., Ongarbaev B.T., Seisenbaeva G.T., Azhmagambetova A.E.,. Zhylkaidarova A.Zh, Lavrentiev I.K., Sagi M.S. - 2021. - Almaty. - JSC "KazNIIOiR". - P. 366.
Larsson, S., Permert, J., Håkansson, N., Näslund, I., Bergkvist, L. and Wolk, A. Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts // British Journal of Cancer. – 2005. - №93(11). - Р.1310-1315.
On approval of target groups subject to screening studies, as well as the rules, volume and frequency of these studies. Minister of Health of the Republic of Kazakhstan dated Oct. 30. - 2020 No. ҚР ДСМ-174/2020. Registered with the Ministry of Justice of the Republic of Kazakhstan No. 21572 Nov. 2. - 2020
Clinical protocol for the diagnosis and treatment of pancreatic cancer No. 57 National Scientific Center for Health Dev. Salidat Kairbekova. - 2019
Ducreux M, Cuhna AS, Caramella C, Hollebecque A, Burtin P, Goéré D, Seufferlein T, Haustermans K, Van Laethem JL, Conroy T, Arnold D; ESMO Guidelines Committee. Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. - 2015 doi: 10.1093/annonc/mdv295. Erratum in: Ann Oncol. - 2017 PMID: 26314780.
Sovak, M.A., Bellas, R.E., Kim, D.W., Zanieski, G.J., Rogers, A.E, Traish, A.M., Sonenshein GE. Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer. J Clin Invest. - 1997. - №100(12). - Р. 2952 doi: 10.1172/JCI119848 PMID: 9399940 PMCID: PMC508506.
Yamada, T., Nakamori, S., Ohzato, H., Oshima, S., Aoki, T., Higaki, N., Sugimoto, K., Akagi, K., Fujiwara, Y., Nishisho, I., Sakon, M., Gotoh, M., Monden, M. Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features. Clin Cancer Res. - 1998. - №4(6). - Р.1527 PMID: 9626473.
Harry, R., Aslanian, J., Lee, H., Marcia, I. C. AGA Clinical Practice Update on Pancreas Cancer Screening in High-Risk Individuals: Expert Review, Gastroenterology. - 2020. - Vol. 159, Is. 1, P. 358-362 ISSN 0016-5085 DOI Crossref.
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