DISTURBANCES IN BLOOD RHEOLOGICAL PROPERTIES DURING PHENYLHYDRAZINE INTOXICATION AND THEIR CORRECTION WITH HYBRID MACROMOLECULAR COMPOUNDS IN RATS
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Authors
O. Aliev
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, pr. Lenina 3, Tomsk, 634050, Russia
A. Sidekhmenova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, pr. Lenina 3, Tomsk, 634050, Russia
E. Popova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, pr. Lenina 3, Tomsk, 634050, Russia
N. Domnina
Institute of Chemistry, St. Petersburg State University, 26 Universitetskii prospect, Petergof, St. Petersburg, 198504, Russia
P. Vlasov
Institute of Chemistry, St. Petersburg State University, 26 Universitetskii prospect, Petergof, St. Petersburg, 198504, Russia
M. Plotnikov
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, pr. Lenina 3, Tomsk, 634050, Russia
Abstract
A single administration of phenylhydrazine at a dose of 50 mg/kg led to a decrease in hematocrit, impaired aggregation and deformability of erythrocytes, which manifested itself in a decrease in the efficiency of oxygen delivery to tissues. Hybrid macromolecular compounds (10 mg/kg intravenously daily for 4 days) attenuated hemorheological parameters disturbances and increased the efficiency of oxygen delivery to tissues.
Keywords
phenylhydrazine intoxication, hybrid macromolecular compounds, hematocrit, erythrocyte aggregation, erythrocyte deformability, oxygen delivery to tissues
Article Details
References
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