INFLUENCE OF CONSUMPTION OF PROBIOTIC DAIRY YOGURT ON GUT MICROBIOME STRUCTURE
Main Article Content
Authors
Zh. Pernebek
National Laboratory Astana, Nazarbayev University, Nur-Sultan, Z05H0P9, Kazakhstan
D. Babenko
Innovative Center ArtScience, Nur-Sultan, Z00T3X6, Kazakhstan
D. Tarzhanova
Department of General Pharmacology, Astana Medical University Nur-Sultan, Z10H9A6, Kazakhstan
I. Uyzbaeva
Department of General Pharmacology, Astana Medical University Nur-Sultan, Z10H9A6, Kazakhstan
Zh. Khassenbekova
Department of General Pharmacology, Astana Medical University Nur-Sultan, Z10H9A6, Kazakhstan
S. Kozhakhmetova
National Center for Biotechnology, Nur-Sultan, Z05K8D5, Kazakhstan
A. Kushugulova
National Laboratory Astana, Nazarbayev University, Nur-Sultan, Z05H0P9, Kazakhstan
Kazakhstan society of researchers of human microbiome, Nur-Sultan, Z05H0P9, Kazakhstan
S. Kozhakhmetov
National Laboratory Astana, Nazarbayev University, Nur-Sultan, Z05H0P9, Kazakhstan
Department of General Pharmacology, Astana Medical University Nur-Sultan, Z10H9A6, Kazakhstan
Kazakhstan society of researchers of human microbiome, Nur-Sultan, Z05H0P9, Kazakhstan
Abstract
This study shows the potential of probiotic dairy product to modulate the gut microbiota. The effect of the product on the intestinal microflora was determined by examining the fecal microflora of rats before and after 4 weeks of adding a fermented milk probiotic product to the diet. Structural changes in the faecal microflora were studied on the basis of sequencing V1-V3 hypervariable target region 16S rRNA gene. Sequencing results showed a decrease in microbiota biodiversity after taking a probiotic product. Nevertheless, enrichment of the microflora with butyrate-producing microorganisms Lachnospiraceae, Ruminococcaceae, Lactobacillales and depletion of Porphyromonadaceae, Eggerthella, Romboutsia, Fusicatenibacter and Bacillus, which are not belong to the order Lactobacillales.
Keywords
Gut microbiome, rats, probiotic yogurt, microbial diversity, short-chain fatty acid
Article Details
References
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