THE EFFECT OF THE IODINE-CONTAINING COMPOUNDS ON GENE EXPRESSION OF PATHOGENIC MICROORGANISMS
Main Article Content
Authors
S.T. Kenesheva
JSC “Scientific Center for Anti-Infectious Drugs, 050060 Almaty, Kazakhstan
A.B. Jumagaziyeva
JSC “Scientific Center for Anti-Infectious Drugs, 050060 Almaty, Kazakhstan
S. Turganbay
JSC “Scientific Center for Anti-Infectious Drugs, 050060 Almaty, Kazakhstan
Zh. A. Iskakbayeva
JSC “Scientific Center for Anti-Infectious Drugs, 050060 Almaty, Kazakhstan
S.M. Jumabayeva
JSC “Scientific Center for Anti-Infectious Drugs, 050060 Almaty, Kazakhstan
G.A. Zhaumitbayeva
JSC “Scientific Center for Anti-Infectious Drugs, 050060 Almaty, Kazakhstan
A.I. Ilin
JSC “Scientific Center for Anti-Infectious Drugs, 050060 Almaty, Kazakhstan
A.A. Azembayev
JSC “Scientific Center for Anti-Infectious Drugs, 050060 Almaty, Kazakhstan
Abstract
The global increase in multidrug resistance highlights the need for new, effective antimicrobial agents. Iodine-containing complexes, due to their broad-spectrum antimicrobial properties, low likelihood of resistance development, and stability under various conditions, represent a promising avenue for the development of innovative therapeutic approaches.
The aim of this study was to collect and analyze research assessing the impact of iodine-containing complexes with organic ligands on the gene expression of certain pathogenic strains of microorganisms with multidrug resistance. Bioinformatics approaches were employed to investigate gene expression, protein interactions, and metabolic pathways, utilizing tools like STRING, KEGG, Reactome, and UniProt. Models of gene and proteome interaction analysis were also used to interpret the data.
Key findings include the suppression of central metabolic cycles, such as the tricarboxylic acid cycle (TCA), increased glycolytic activity, a shift in metabolism toward anaerobic respiration, and activation of oxidative stress defense systems. The study also highlights changes in gene expression associated with membrane remodeling, DNA repair, regulation of virulence factors, and nutrient transport. These adaptive responses reflect the multifaceted antimicrobial action of iodine-containing complexes, which target key cellular components and processes, making them highly effective against multidrug-resistant pathogens.
Iodine-containing complexes exhibit high antimicrobial potential due to their ability to disrupt essential bacterial life processes, impairing metabolism, structure, and adaptive mechanisms. Further research into the molecular mechanisms of iodine’s action and its effects on pathogen virulence could open new avenues for addressing the challenge of antibiotic resistance.
Keywords
pathogenic microorganisms, multidrug resistance, gene expression, iodine-containing compounds, mechanism of action, central metabolism
Article Details
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