ANTIMICROBIAL AND ANTIMALARIAL ACTIVITIES OF EXTRACTS ISOLATED FROM HERBAL PLANT POLYGONUM HYDROPIPER
Main Article Content
Authors
A.S. Shevchenko
al-Farabi Kazakh National University, Department of chemistry and chemical technology, 71, al-Farabi avenue, Almaty, 050040, Kazakhstan
R.A. Muzychkina
al-Farabi Kazakh National University, Department of chemistry and chemical technology, 71, al-Farabi avenue, Almaty, 050040, Kazakhstan
S.A. Ross
National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, Mississippi, 38677, United States
Abstract
In the present article, we examined the antimicrobial, antifungal and antimalarial activities of two crude extracts 1, 4 (ethanol and methanol) and two fractions 2, 3 (dichloromethane and ethyl acetate) what isolated from Polygonum hydropiper. Antimicrobial activity was tested against Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Cryptococcus neoformans, Aspergillus fumigatus, Klebsiella pneumonia and methicillin resistant Staphylococcus aureus (MRSa). Samples 1 and 3 were effective against A. fumigates. Sample 1 was mild active against K. pneumoniae with IC50 of 9.0 μg/mL. Sample 2 demonstrated mild activity against E. coli and C. neoformans with IC50 of 10.0 and 13.0 μg/mL, respectively.
Keywords
Polygonum hydropiper, flavonoids, extractive substances, antibacterial, antifungal and antimalarial activity, P. falciparum
Article Details
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