BIOLOGY, EPIDEMIOLOGY, GENETIC CHARACTERISTICS, AND RESEARCH PRIORITIES OF WEST NILE VIRUS
Main Article Content
Authors
A.O. Bissenbay
National Center for Biotechnology, Almaty Branch, 14D Zhahanger str., Almaty, 050054, Kazakhstan
A.V. Zhigailov
National Center for Biotechnology, Almaty Branch, 14D Zhahanger str., Almaty, 050054, Kazakhstan
A.S. Neupokoyeva
National Center for Biotechnology, Almaty Branch, 14D Zhahanger str., Almaty, 050054, Kazakhstan
D.A. Naizabayeva
National Center for Biotechnology, Almaty Branch, 14D Zhahanger str., Almaty, 050054, Kazakhstan
Y.A. Skiba
National Center for Biotechnology, Almaty Branch, 14D Zhahanger str., Almaty, 050054, Kazakhstan
A.M. Dmitrovskiy
National Center for Biotechnology, Almaty Branch, 14D Zhahanger str., Almaty, 050054, Kazakhstan
Zh.Zh. Shapiyeva
National Center for Biotechnology, Almaty Branch, 14D Zhahanger str., Almaty, 050054, Kazakhstan
Abstract
West Nile fever (WNF) is an acute viral, natural foci infectious disease with a zoonotic mechanism of transmission. WNF has a high incidence in countries with a temperate climate in the summer-fall season. The causative agent is West Nile virus (WNV), which belongs to the Flavivirus genus of the Flaviviridae family. WNV was first isolated in the West Nile district of Uganda in 1937 from the blood of a native Ugandan woman. Several sporadic cases were then reported in Israel, Egypt, India, France, and South Africa from the 1950s to 1980s. However, WNV became a global public health concern after introduction of the virus in New York in 1999, which consequently led to its massive spillover across almost all of the United States, Canada, and Central America. In the 1990s, several significant outbreaks of WNF also occurred in Russia. The virus currently circulates in almost all countries of the African continent, Asia (mainly on the Hindustan subcontinent), Israel, and Europe. In Kazakhstan, WNF cases have mainly been reported in territories bordering Russia and in some areas of the Turkestan oblast. Birds serve as amplifier hosts, and mosquitoes, mainly of the genus Culex, are the primary vectors. Human and horses are the dead-end hosts of the virus. The clinical manifestations of WNV infection in humans range from asymptomatic illness to encephalitis, leading to various neurodegenerative diseases. This article reviews current data on the biology, epidemiology, ecology, geographical distribution, virology, pathology, structure, and genome characteristics of WNV, as well as the main laboratory diagnosis methods and further research priorities.
Keywords
West Nile fever (WNF), West Nile virus (WNV), mosquito, Culex, Flavivirus, genotype
Article Details
References
David S., Abraham A.M. Epidemiological and clinical aspects on West Nile virus, a globally emerging pathogen. Infectious diseases, 2016, vol. 48, no.8, pp. 571-586. PMID 27207312, doi: 10.3109/23744235.2016.1164890.
Valiakos G., Athanasiou L.V., Touloudi A., Papatsiros V., Spyrou V., Petrovska L., Billinis C. West Nile Virus: Basic Principles, Replication Mechanism, Immune Response and Important Genetic Determinants of Virulence. Viral replication, 2013, pp. 43-68. doi: 10.5772/55198.
Smithburn K.C., Hughes T.P., Burke A.W., Paul J.H. A Neurotropic Virus Isolated from the Blood of a Native of Uganda. Am. J. Trop. Med. Hyg, 1940, s1-20, no.4, pp. 471-92. doi.org/10.4269/ajtmh.1940.s1-20.471.
Anis E., Grotto I., Mendelson E., Bin H., Orshan L., Gandacu D., Warshavsky B., Shinar E., Slater P.E., Lev B. West Nile fever in Israel: the reemergence of an endemic disease. J Infect, 2014, vol.68, no.2, pp. 170-5. doi: 10.1016/j.jinf.2013.10.009
Bondre V.P., Jadi R.S., Mishra A.C. West Nile virus isolates from India: evidence for distinct genetic lineage. J Gen Virol. 2007, vol. 88, pp. 875-884. PMID: 17325360, doi: 10.1099/vir.0.82403-0.
Bakonyi T., Ivanics E., Erdélyi K., Ursu K., Ferenczi E., Weissenböck H. Lineage 1 and 2 strains of encephalitic West Nile virus, central Europe. Emerg Infect Dis. 2006, vol.12, no.4, pp.618-23. PMID: 16704810, doi: 10.3201/eid1204.051379.
May F.J., Davis C.T., Tesh R.B., Barrett A.D. Phylogeography of West Nile virus: from the cradle of evolution in Africa to Eurasia, Australia, and the Americas. J Virol, 2011, vol. 85, no.6, pp. 2964-74. PMID: 21159871, doi: 10.1128/JVI.01963-10.
Rizzoli A., Jimenez-Clavero M.A., Barzon L., Cordioli P., Figuerola J., Koraka P., Martina B., Moreno A., Nowotny N., Pardigon N., Sanders N., Ulbert S., Tenorio A. The challenge of West Nile virus in Europe: knowledge gaps and research priorities. Eurosurveillance, 2015, vol.20, no.20. doi:10.2807/1560-7917.es2015.20.20.21135.
Prilipov A.G. Genetic characterization of West Nile virus strains (Published doctoral dissertation). Federal State Budgetary Institution “Federal Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamalei” of the Ministry of Health of the Russian Federation, 2015, Moscow, Russia.
Lvov D.K., Butenko А.М., Gajdamovich S.J, Larichev V.F., Leshhinskaja E.V., Lazarenko V.V., Petrov V.R., Trihanov S.T., Hutoreckaja N.V., Shishkina E.O., Jashkov A.B. The epidemic of meningoencephalitis in the Krasnodar region and Volgograd oblast caused by the West Nile virus. Vopr.virusol. 2000, vol.1, pp.37-38.
Lvov D.K., Butenko А.М., Vyshemirskij O.I., Gajdamovich S.J., Gromashevskij V.L., Larichev V.F., Morozova T.N., Skvorcova T.M., Hutoreckaja N.V., Shishkina E.O., Jashkov A.B., Platonov A.E., Shipulin G.A., Shipulina O.Ju., Zhukov A.N., Lazorenko V.V., Rusakova N.V., Azarjan A.A., Grishanova A.P., Glimzjanov H.M., Grinkova E.P. Isolation of West Nile fever virus from infected people during an outbreak in the Volgograd and Astrakhan oblasts. Vopr.virusol, 2000, vol. 3, pp. 56-64.
Hubalek Z., Halouzka J. West Nile fever-a reemerging mosquito-borne viral disease in Europe. Emerg Infect Dis, 1999, vol.5, no.5, pp. 643-50. PMID: 10511520, doi:10.3201/eid0505.990505.
Tsai T.F., Popovich F., Cernescu C., Campbell G.L., Nedelcu N.I. West Nile encephalitis epidemic in southeastern Romania. Lancet, 1998, vol.352, no.9130, pp. 767-71. PMID: 9737281, doi: 10.1016/s0140-6736(98)03538-7.
Briese T., Jia X.Y., Huang C., Grady L.J., Lipkin W.I. Identification of a Kunjin/West Nile-like flavivirus in brains of patients with New York encephalitis. Lancet.1999, vol.354, no.9186, pp. 1261-2. PMID:10520637, doi: 10.1016/s0140-6736(99)04576-6.
Gubler D.J. The continuing spread of West Nile virus in the western hemisphere. Clin Infect Dis. 2007, vol.45, no.8, pp. 1039-46. PMID: 17879923, doi: 10.1086/521911
Lanciotti R.S., Roehrig J.T., Deubel V., Smith J., Parker M., Steele K., Crise B., Volpe K.E., Crabtree M.B., Scherret J.H., Hall R.A., MacKenzie J.S., Cropp C.B., Panigrahy B., Ostlund E., Schmitt B., Malkinson M., Banet C., Weissman J., Komar N., Savage H.M., Stone W., McNamara T., Gubler, D.J. Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Science, 1999, vol.286, no.5448, pp. 2333-7, doi:10.1126/science.286.5448.2333.
Lvov D.K., Butenko A.M., Gromashevsky V.L., Kovtunov A.I., Prilipov A.G., Kinney R., et al. West Nile virus and other zoonotic viruses in Russia: examples of emerging-reemerging situations. Arch Virol Suppl, 2004, vol.18, no.18, pp. 85-96. PMID:15119764.
Murata R., Hashiguchi K., Yoshii K., Kariwa H., Nakajima K., Ivanov L.I., Leonova G.N., Takashima I. Seroprevalence of West Nile virus in wild birds in far eastern Russia using a focus reduction neutralization test. Am J Trop Med Hyg, 2011, vol.84, no.3, pp. 461-5. PMID: 21363987, doi:10.4269/ajtmh.2011.09-0714.
Kovtunov A. I., Kolobuhina L. V., Moskvina T. M., Shishkina E. O., Dzharkenov A. F., Kisteneva D. N., L'vov D. N., Shhelkanov M. Ju., Aristova V. A., Larichev V.F., Zlobina L. V., Grishanova A. P., Grenkova E. P., Arshba T. E., Oganesjan Ju. V. Morbidity and infection of the population of the Astrakhan oblast by West Nile fever in 2002. Vopr.virusol, 2003, vol. 5, pp.9-28.
Majkanov N.S., Ajazbaev T.Z. Epidemic significance and mosquito species composition (Culicidae) in Western Kazakhstan. National Priorities of Russia. 2016, vol.4 (22). Retrieved from URL.
Temirbekova Zh.T., The results of many years of research on arboviruses in Kazakhstan (1961-1982). Viral Hemorrhagic Fever. 1971, pp. 7-20.
Karimov S.K., Zhumatov Kh.Zh., Firsova N.M. Detection of antibodies to group B arboviruses in the population of the Kyzylorda oblast of the Kazakh SSR. Actual problems of virology and prevention of viral diseases digest, 1972, pp. 291-292. (RU)
Stavickij A.V. Study of susceptibility of wild ducks to West Nile virus. Environmentally Related Bird Viruses. Omsk institute for natural foci infections, Omsk, 1971, pp. 18-19.
Fedotova T.N., Stavskyi А.V., Fedorov V.G. West Nile fever in experimentally infected rooks. Environmentally Related Bird Viruses. Omsk institute for natural foci infections, Omsk. 1971, pp. 19-22.
Komar N., Langevin S., Hinten S., Nemeth N., Edwards E., Hettler D., Davis B., Bowen R., and Bunning M. Experimental infection of North American birds with the New York 1999 strain of West Nile virus. Emerg Infect Dis, 2003, vol.9, no.3, pp. 311-22. PMID: 12643825, doi:10.3201/eid0903.020628.
Chancey C., Grinev A., Volkova E., Rios M. The global ecology and epidemiology of West Nile virus. BioMed Research International, 2014, vol. 2015, pp. 1-20. doi.org/10.1155/2015/376230.
Meulen M.V., Pensaert M. B., Nauwynck H. J. West Nile virus in the vertebrate world. Archives of Virology, 2005, vol. 150, no. 4, pp. 637–657. PMID: 15662484, doi:10.1007/s00705-004-0463-z.
Go ́mez A., Kramer L. D., Dupuis A. P. Experimental infection of eastern gray squirrels (Sciurus carolinensis) with West Nile virus. The American Journal of Tropical Medicine and Hygiene, 2008, vol. 79, no.3, pp. 447–451. PMID: 18784241.
Platt K. B., Tucker B. J., Halbur P. G. West Nile virus viremia in eastern chipmunks (Tamias striatus) sufficient for infecting different mosquitoes. Emerging Infectious Diseases, 2007, vol. 13, no.6, pp. 831–837. PMID: 17553220, doi: 10.3201/eid1306.061008.
Turell M. J., Sardelis M. R, O’Guinn M. L., Dohm D. J. Potential vectors of West Nile virus in North America. Current Topics in Microbiology and Immunology, 2002, vol. 267, pp. 241–252. doi.org/10.1007/978-3-642-59403-8_12.
Andreadis T.G., Anderson J.F., Vossbrinck C.R. Mosquito surveillance for West Nile virus in Connecticut, 2000: isolation from Culex pipiens, Cx. restuans, Cx. salinarius, and Culiseta melanura. Emerg Infect Dis, 2001, vol.7, no. 4, pp. 670-4. doi: 10.3201/eid0704.010413.
Hayes E.B., Komar N., Nasci R.S., Montgomery S.P., O'Leary D.R., Campbell G.L. Epidemiology and transmission dynamics of West Nile virus disease. Emerg Infect Dis., 2005, vol.11, no.8, pp. 1167-73. PMID:16102302, doi:10.3201/eid1108.050289a.
Smithburn K. C., Jacobs R. H. Neutralization-tests against neurotropic viruses with sera collected in central Africa. Journal of Immunology, 1942, vol. 44, pp. 9–23.
Kokernot R.H., Smithburn K. C, Weinbren M. P. Neutralizing antibodies to arthropod-borne viruses in human beings and animals in the Union of South Africa. Journal of Immunology,1956, vol. 77, no.5, pp. 313–323. PMID:13385500.
Bernkopf H., Levine S., Nerson R. Isolation of West Nile virus in Israel. The Journal of Infectious Diseases, 1953. vol. 93, no. 3, pp. 207–218. PMID:13109233, doi: 10.1093/infdis/93.3.207.
European Centre for Disease Prevention and Control. (2018). West Nile virus in Europe in 2018. Retrieved from URL.
Centers for Disease control and prevention. (2018-19). West Nile virus: preliminary maps and data for 2018-2019. Retrieved from URL.
Public Health Agency of Canada. (2018). Surveillance of West Nile virus. Retrieved from URL.
Shaimerdenova B.E., Kulemin M.V., Atovullayeva L.M., Nurmakhanov N.I. (2019, April). Results of studies on tick-borne encephalitis and West Nile fever on the territory of Turkestan oblast. Proceedings of scientific-practical conference “Modern technologies of diagnosis, treatment, prevention of infectious and parasitic diseases”, Bukhara, Uzbekistan.
Yang J.S., Ramanathan M.P., Muthumani K., Choo A.Y., Jin S.H., Yu Q.C., Hwang D.S., Choo D.K., Lee M.D., Dang K., Tang W., Kim J.J., and Weiner D.B. Induction of inflammation by West Nile virus capsid through the caspase-9 apoptotic pathway. Emerg Infect Dis., 2002, vol.8, no.12, pp. 1379-84. PMID:12498651, doi:10.3201/eid0812.020224.
Simmonds P., Becher P., Bukh J., Gould E.A., Meyers G., Monath N., et al. ICTV Virus Taxonomy Profile: Flaviviridae. Journal of general virology, 2017, vol. 98, no.1, pp. 2–3. PMID: 28218572, doi: 10.1099/jgv.0.000672
Heinz F. X., Stiasny K. Flaviviruses and their antigenic structure. Journal of Clinical Virology, 2012, vol. 55, no.4, pp. 289– 295. PMID:22999801, doi:10.1016/j.jcv.2012.08.024.
Brinton M.A. The molecular biology of West Nile virus: a new invader of the Western hemisphere. Annual Review of Microbiology, 2002, vol. 56, pp. 371–402. doi.org/10.1146/annurev.micro.56.012302.160654.
Brinton M.A. Replication Cycle and Molecular Biology of the West Nile Virus. Viruses, 2014, vol. 6, no.1, pp. 13-53. doi: 10.3390/v6010013. PMID: 24378320.
International Committee on Taxonomy of Viruses ICTV. (2018). Genus: Flavivirus. Retrieved from URL.
Mackenzie J., Williams S.D. The zoonotic flaviviruses of southern, south-eastern and eastern Asia, and Australasia: the potential for emergent viruses. Zoonoses Public Health, 2009, vol. 56, no.6-7, pp. 338-56. PMID:19486319, doi:10.1111/j.1863-2378.2008.01208.
Bondre V.P., Jadi R.S., Mishra A.C., Yergolkar P.N., Arankalle V.A. West Nile virus isolates from India: evidence for a distinct genetic lineage. J Gen Virol, 2007, vol. 88, no.3, pp. 875-84.
Lvov D., Butenko A.K., Gromashevsky M.V., Kovtunov L.A., Prilipov A. G., et al. West Nile virus and other zoonotic viruses in Russia: examples of emerging-reemerging situations. Arch. Virol. Suppl, 2004, vol. 18, pp. 85-96.
Lustig Y., Mannase B., Koren R., et al. Superiority of West Nile virus RNA detection in whole blood for diagnosis of acute infection. J Clin Microbiol. 2016, vol. 54, no.9, pp. 2294-7. doi: 10.1128/JCM.01283-16.
Vazquez A, Herrero L., Negredo A., Hernandez L., Sanchez-Seco M.P., Tenorio A. Real-time PCR assay for detection of all known lineages of West Nile virus. Journal of Virological methods, 2016, vol. 236, pp.266-270. doi: 10.1016/j.jviromet.2016.07.026.