Gut Microbiota Modulation In Diabetic Patients

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S.S. Kozhakhmetov

National Laboratory Astana, Nazarbayev University, 53, Kabanbay batyr ave., Nur-Sultan, 010000, Kazakhstan
Kazakhstan Association of Human Microbiome Researchers, Nur-Sultan, 010000, Kazakhstan
Innovative Center ArtScience, Nur-Sultan, 010000, Kazakhstan

N. Mukhanbetzhanov

National Laboratory Astana, Nazarbayev University, 53, Kabanbay batyr ave., Nur-Sultan, 010000, Kazakhstan
Innovative Center ArtScience, Nur-Sultan, 010000, Kazakhstan

А.R Kushugulova

National Laboratory Astana, Nazarbayev University, 53, Kabanbay batyr ave., Nur-Sultan, 010000, Kazakhstan
Kazakhstan Association of Human Microbiome Researchers, Nur-Sultan, 010000, Kazakhstan


Metabolic disorders and diabetes mellitus are one of the major complex public health problems in the world, and in fact are becoming a global epidemic. It is associated with an increased risk of a large number of complications, including dyslipidemia, cardiovascular disease. The microbiota modulates inflammation, metabolizes indigestible food components, affects intestinal permeability, glucose and lipid metabolism, insulin sensitivity, and overall energy homeostasis. The study investigated the effect of a multistrain probiotic on the intestinal microflora in diabetic patients. As a result of the work carried out, it was shown that the microbiome of patients with diabetes mellitus differs from normal and is depleted in bifidobacteria and some butyrate producers, such as Subdoligranulum, but enriched in Prevotella. The use of a multi-strain probiotic has led to an increase in the biodiversity of the intestinal microflora. Also, in the fecal samples, the content of acetate and butyrate increased, while the concentration of propionate decreased markedly.


microbiome, gut, short-chain fatty acids, probiotic, taxon, diversity

Article Details


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