IMMUNOBIOTICS AND THEIR EFFECT ON THE HUMAN IMMUNE SYSTEM IN HEALTH AND DISEASE
Main Article Content
Authors
S.A. Starovoitova
National University of Food Technologies, 68, Vladimirskaya str., Kiev, 0160, Ukraine
A.V. Karpov
National University of Food Technologies, 68, Vladimirskaya str., Kiev, 0160, Ukraine
Abstract
This article summarizes previous studies investigating the influence of the microbiota on the immune system in health and disease. The main stages of formation of the human intestinal microflora and related factors, as well as its normal physiological functions are discussed. The diseases associated with disruption of the microbiota, in which the use of probiotics results in immunological disorders of varying nature and severity is also discussed. Moreover, we outline the mechanisms that regulate the diversification of immune responses to pathogenic and commensal microorganisms. The effects of normal flora microorganisms on innate and adaptive immunity are characterized. In addition, human inflammatory diseases associated with microbiota disorders are described. The biological properties of probiotics are reviewed in the context of their modulatory effect on the inflammatory response. Accordingly, the immunomodulatory potential of probiotic microorganisms is analysed. In conclusion, this article offers recommendations on strategies for effective application of the immunomodulatory activity of probiotic microorganisms and probiotics.
Keywords
gut microbiota, immunomodulation, immunobiotics, inflammation, probiotic functions
Article Details
References
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