ASSOCIATION OF POLYMORPHISMS RS4607517 AND RS7566605 WITH RISK OF DEVELOPING TYPE 2 DIABETES AND OBESITY IN A KAZAKH POPULATION
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Authors
N.S. Sikhayeva
National center for biotechnology, Korgaldzyn av., 13/5, Astana, 010000, Kazakhstan
L.N. Gumilyov Eurasian National University, Munaitpasova str., 5, Astana, 010000, Kazakhstan
Zh.M. Dzharmukhanov
National center for biotechnology, Korgaldzyn av., 13/5, Astana, 010000, Kazakhstan
A.T. Nakysh
Astana Medical University, Koshkarbayeva str., 66, Astana, 010000, Kazakhstan
S.K. Smagulova
City polyclinic №4,Shevchenko str., 4, Astana, 010000, Kazakhstan
S.A. Shaimerdenov
City polyclinic №4,Shevchenko str., 4, Astana, 010000, Kazakhstan
S.A. Baidurin
Astana Medical University, Koshkarbayeva str., 66, Astana, 010000, Kazakhstan
E.V. Zholdybayeva
National center for biotechnology, Korgaldzyn av., 13/5, Astana, 010000, Kazakhstan
E.M. Ramankulov
National center for biotechnology, Korgaldzyn av., 13/5, Astana, 010000, Kazakhstan
L.N. Gumilyov Eurasian National University, Munaitpasova str., 5, Astana, 010000, Kazakhstan
Abstract
Diabetes and obesity are multifactorial diseases that are major global health problems. The pathogenic mechanisms of these diseases include several pathways operating under the influence of the interaction of genetic and environmental factors. According to numerous studies, there are multiple loci that contribute to the risk of multifactorial (polygenic) diseases. It was previously demonstrated that polymorphisms in the GCK, YKT6and INSIG2 genes are associated with the risk of type 2 diabetes and obesity in different populations. This study aimed to investigate the association of GCK, YKT6 and INSIG2 allelic polymorphisms and risk of type 2 diabetes and obesity in a Kazakh population. The study included patients diagnosed with type 2 diabetes. The control group consisted of healthy volunteers who were invited to participate in the study during a routine health examination. A total of 662 participants of Kazakh nationality were genotyped for two single nucleotide polymorphisms: rs4607517 and rs7566605. The results of genetic analysis revealed a statistically significant association between polymorphisms inGCK, YKT6 and INSIG2 and risk of type 2 diabetes (rs4607517: OR = 0.70, CI = 0.51–0.95, p = 0.024 in the additive model) and obesity (rs4607517: OR = 0.20, CI = 0.03–0.82, p = 0.045; rs7566605: OR = 1.82, CI = 1.11–3.02, p = 0.018 in the recessive model). In addition, these polymorphisms were associated with different blood parameters, including hemoglobin, erythrocytes, and mean platelet volume. In conclusion, we observed a statistically significant association between GCK, YKT6 and INSIG2 polymorphisms and risk of developing type 2 diabetes and obesity in a Kazakh population.
Keywords
Single nucleotide polymorphism, type 2 diabetes, obesity, Kazakh population
Article Details
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