REVIEW: REPROGRAMMING OF CANCER CELLS WITH VARIOUS EMBRYONIC MICROENVIRONMENTS
Main Article Content
Authors
D. Mektepbayeva
National Laboratory Astana, Nazarbayev University, KabanbayBatyr Ave, 53, Astana, 010000, Kazakhstan
D. Janzakova
Nazarbayev University, KabanbayBatyr Ave, 53, Astana, 010000, Kazakhstan
M. Shaimerdenova
National Laboratory Astana, Nazarbayev University, KabanbayBatyr Ave, 53, Astana, 010000, Kazakhstan
O. Karapina
Nazarbayev University Research and Innovation System, KabanbayBatyr Ave, 53, Astana, 010000, Kazakhstan
X. Mu
University of Texas Health Science Center, 3SCR6 #3706 1881 East Road, Houston, TX 77054, USA
A. Kenneth
Alibek Kenneth, Locus Solutions, LLC, 30500 Aurora Rd Ste 180 Solon,OH 44139-2776, USA
D. Akilbekova
National Laboratory Astana, Nazarbayev University, KabanbayBatyr Ave, 53, Astana, 010000, Kazakhstan
Abstract
Recent studies have demonstrated that common factors present in aggressive cancer cells and embryonic progenitors influence cancer aggressiveness. This review will summarize the cancer-related properties of various embryonic microenvironments. The anticancer effects of embryonic microenvironments on various types of cancer cells and tumors are associated with epigenetic alterations and down regulation of tumor-suppressor genes and the Nodal signaling pathway. The ability to reprogram the tumorigenic phenotype of cancer cells depends on the stage and type of embryonic microenvironment, and reprogramming capacity significantly decreases after organogenesis. Understanding the mechanisms underlying the molecular reprogramming of cancer cells in various embryonic models will help identify potential targets for cancer therapy.
Keywords
Cancer, cell reprogramming, epigenetics, embryonic microenvironments, differentiation
Article Details
References
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