MODERN MARKET OF INFLUENZA VACCINE PRODUCTION
Main Article Content
Authors
N.D. Deryabina
Institute of Plant Biology and Biotechnology, 45, Timiryazev str., 050040, Almaty
al-Farabi Kazakh National University, 71, al-Farabi Ave, 050040, Almaty
D.A. Gritsenko
Institute of Plant Biology and Biotechnology, 45, Timiryazev str., 050040, Almaty
K.P. Aubakirova
Institute of Plant Biology and Biotechnology, 45, Timiryazev str., 050040, Almaty
S.S. Baizhumanova
Institute of Plant Biology and Biotechnology, 45, Timiryazev str., 050040, Almaty
N.N. Galiakparov
Institute of Plant Biology and Biotechnology, 45, Timiryazev str., 050040, Almaty
Abstract
Influenza virus is a negative stranded RNA virus that causes seasonal flu infections and is the reason for several epidemics that have occurred in the previous century. The high mutagenicity of the virus is mediated by error-prone RNA polymerase, which incorporates mutations into the viral genome during every replication cycle. Mutations lead to the emergence of new virus clades within subgroups, which leads to the periodic reevaluation of seasonal and pandemic vaccine contents. Vaccines usually prevent severe symptoms of flu infection only if a patient is vaccinated and infected with the same influenza subtype.
Hence, there is the constant possibility of the emergence of new influenza pandemic virus. This could be prevented by either increasing the scope of vaccine efficiency or by developing methods of rapid vaccine production against any emerging subtype or clade.
This article reviews vaccines against influenza virus subtypes, and modern and prospective alternative ways to increase vaccine range, breadth, and efficiency in both healthy adults and people in risk groups.
Keywords
vaccine, influenza, epidemics, hemagglutinin, neuraminidase, T-cells
Article Details
References
Nicolas H. Acheson. Fundamentals of molecular virology. John Wiley and Sons, 2011, chapter 18, pp. 210-223.
Velislava N. Petrova, Colin A. Russell. The evolution of seasonal influenza virus. Nature Reviews Microbiology, 2018, vol. 16, pp. 47-60. Crossref
Aartjan J. W. te Velthuis, Ervin Fodor. Influenza virus RNA polymerase: insights into the mechanism of viral RNA synthesis. Nature Reviews Microbiology, 2016, vol. 14, pp. 479- 493. Crossref
Sook-San Wong, Richard J. Webby. Traditional and new influenza vaccines. Clinical microbiology reviews, 2013, vol. 26, no. 3, pp. 476-492.
Dormitzer, P. R. Rapid production of synthetic influenza vaccines. Current Topics in Microbiological Immunology, 2015, vol. 386, pp. 237–273
Katherine Houser and Kanta Subbarao, Influenza vaccines: challenges and solutions, Cell host and microbe mini review, Cell press, 2015, vol. 17, pp. 295-300. Crossref.
Young-Tae Lee, Ki-Hye Kim, Eun-Ju Ko et al. New vaccines against influenza virus. Clinical and Experimental Vaccine Research, 2014, vol. 3, no. 1, pp. 12-28. Crossref
Helder I. Nakaya, Jens Wrammert, Eva K. Lee et al. Systems biology of vaccination for seasonal influenza in humans. Nature Immunology, 2011, vol. 12, pp. 786-795. Crossref
Francesco Berlanda Scorza, Vadim Tsvetnitsky, John J. Donnelly, Universal influenza vaccines: Shifting to better vaccines. Vaccine, 2016, vol. 34, pp. 2926-2933. Crossref
Robert B. Belshe, Katryn M. Edwards, Timo Vesikari et al. Live attenuated versus inactivated influenza vaccine in infants and young children. The New England Journal of Medicine, 2007, vol. 356, pp. 685-696. DOI: 10.1056/NEJMoa065368
Florian Krammer, Peter Palese. Influenza virus hemagglutinin stalk-based antibodies and vaccines. Current Opinion in Virology, 2013, vol. 3, no. 5, pp. 521-530. Crossref
Lulan Wang, Su-Wang Lui, Hsiang-Wen Hen et al. Generation of live attenuated vaccine that elicits broad protection in mice and ferrets. Cell Host and Microbe, 2017, vol. 21, pp. 334-343. Crossref
Kathleen L. Coelingh, Catherine J. Luke, Hong Jin, Kawsar L. Talaat. Development of live attenuated influenza vaccines against pandemic influenza strains. Expert Review of Vaccines, 2014, vol. 13, pp. 855-871. Crossref
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Saranya Sridhar, Karl A. Brokstad, and Rebecca J. Cox, Influenza vaccination strategies: comparing inactivated and live attenuated influenza vaccines. Vaccines, 2015, vol. 3, no. 2, 373-389. Crossref
Yoko Shoji, Jessica A. Chichester, Mark Jones et al. Plant-based rapid production of recombinant subunit hemagglutinin vaccines targeting H1N1 and H5N1 influenza. Human Vaccines, 2010, vol. 7, pp. 41-50. Crossref
François Le Mauff, Geneviève Mercier, Philippe Chan, Carole Burel, et al, Biochemical composition of haemaggulutinin-based influenza virus-like particle vaccine produced by transient expression in tobacco plants. Plant Biotechnology Journal, 2015, vol. 13, pp. 717-725, doi:10.1111/pbi.12301
Marc-Andre D'Aoust, Pierre-Olivier Lavoie, Manon M. J. Couture et al. Influenza virus‐like particles produced by transient expression in Nicotiana benthamiana induce a protective immune response against a lethal viral challenge in mice. Plant Biotechnology Journal, 2008, vol. 6, pp. 930–940 Crossref
Stylianos Bournazos, Jeffrey V. Ravetch. Attenuated vaccines for augmented immunity. Cell host and microbe, 2017, vol. 21, no. 3, pp. 314-315, Crossref
Brandon M. Giles, Stephanie J. Bissel, Dilhari R. DeAlmeida et al. Antibody breadth and protective efficacy are increased by vaccination with computationally optimized hemagglutinin but not with polyvalent hemagglutinin-based H5N1 virus-like particle vaccines. Clinical and Vaccine Immunology, 2012, vol. 19, no. 2, pp. 128-139. DOI: 10.1128/CVI.05533-11
Ralph A. Tripp, S. Mark Tompkins. Virus-vectored influenza virus vaccines. Viruses, 2014, vol. 6, no. 8, pp. 3055-3079. ttps://doi.org/10.3390/v6083055
Derek T. O’Hagan, Gary S. Ott, Gary van Nest et al. The history of MF59® adjuvant: a phoenix that arose from the ashes. Expert Review of Vaccines, 2013, vol. 12, pp. 13–30. Crossref